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Image Search Results
Journal: Cancers
Article Title: Computational Optimization of Irradiance and Fluence for Interstitial Photodynamic Therapy Treatment of Patients with Malignant Central Airway Obstruction
doi: 10.3390/cancers15092636
Figure Lengend Snippet: FEM-Based Treatment Plan for I-PDT of MCAO. The above figure shows a representative treatment plan and simulation results for a patient with MCAO that was treated with I-PDT. ( a ) High-resolution diagnostic CT scan. The treating physician segmented the tumor treatment volume (in red) and then the surrounding critical structures were segmented. The total tumor volume was 26.1 cm 3 . For this patient, segmentations were performed for the pulmonary artery (in purple), ascending and descending aorta (in pink), bronchus (in green), and vertebra (in yellow), and then for the tissue surrounding the tumor (not shown). These segmentations were used to create 3D CAD models that could be imported into the FEM software, which in this case was Comsol. ( b ) Three-dimensional mesh of the tumor (in red), pulmonary artery (in purple), aortic arch (in pink), and bronchus (in green). The mesh was created from the 3D CAD models in Comsol and used for our FEM simulations of light distribution. For this patient, the light irradiance and fluence distribution was computed for the tumor, surrounding normal tissue, pulmonary artery, and the aortic arch. ( c ) Fiber placement from the bronchus and into the tumor geometry. The plan was to insert 4 CDFs with illumination lengths of 1.5 cm. Each fiber would emit 240 mW/cm for 750 s. ( d ) Resulting irradiance distribution. Based on the treatment plan, 99.97% of the tumor volume would receive ≥8.6 mW/cm 2 . The irradiance ranged 7–1528 mW/cm 2 . ( e ) Resulting rate-based light dose (the total fluence calculated when the irradiance ≥ 8.6 mW/cm 2 ). Based on the treatment plan, 79.6% of the tumor volume would have received the effective rate-based light dose (i.e., ≥8.6 mW/cm 2 and 45 J/cm 2 ). This volume of the tumor is indicated in red in ( e ).
Article Snippet: The segmented scans were then reconstructed to create a
Techniques: Diagnostic Assay, Computed Tomography, Software